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Phenotyping Platform
In Japan Mouse Clinic, we have developed the two pipelines which are constructed with comprehensive test items.
Pipeline 1: Comprehensive screen
Comprehensive test items examining metabolic, blood/hematic, osseous/skeletal, cancer, cardiovascular, sensory, skin/fur, and neural/behavioral characteristics, construct pipeline 1.
| Comprehensive screen | |||||||||||||||||||||
| Test ID | Screens | Methods | Age (Weeks) | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | |||
| P1-01 | Morphology/ Behavioral/ Sensory |
Modified-SHIRPA | |||||||||||||||||||
| P1-02 | Blood | Hematological test | |||||||||||||||||||
| P1-03 | Clinical biochemical test | ||||||||||||||||||||
| P1-04 | Metabolism | IPGTT (Intraperitoneal glucose tolerance test) | |||||||||||||||||||
| P1-05 | Adipocytokine test※ | ||||||||||||||||||||
| P1-06 | Sensory | Funduscopy | |||||||||||||||||||
| P1-07 | Morphology | X-ray | |||||||||||||||||||
| P1-08 | Metabolism | Body fat percentage and Bone Mineral Density (DEXA) | |||||||||||||||||||
| P1-09 | Cardiovascular | ECG(Electrocardiography) | |||||||||||||||||||
| P1-10 | Immunology | FACS | |||||||||||||||||||
| P1-11 | Pathology | Autopsy, Histology | |||||||||||||||||||
※ Optional test
Pipeline 2: Behavioral screen
| Behavioral screen | Test ID | Screens | Methods | Age (Weeks) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | ||||||
| P2-01 | Behavior/ Neurology/ Psychiatry |
Light/dark transition | ||||||||||||
| P2-02 | Open-field test | |||||||||||||
| P2-03 | Crawley's social interaction test | |||||||||||||
| P2-04 | Home-cage activity | |||||||||||||
| P2-05 | Y maze | |||||||||||||
| P2-06 | Fear-conditioning test | |||||||||||||
| P2-07 | ASR/PPI | |||||||||||||